NEUPHORIC Pre-Workout | Full Product Breakdown

The industry-changing pre-workout, NEUPHORIC , may be seen as a newcomer to the industry, but don't let this fool you. Its formulation took years of perfecting to hand-pick every ingredient, include them at the right doses and ultimately make the best pre-workout on the market.

That being said, The Formula prides itself on its dedication to educating everyone, and providing a space where everyone can learn. Most pre-workout companies include certain ingredients but they don't actually explain why they have included them, or what they actually do.

Read this article for a full product breakdown of every ingredient in NEUPHORIC pre-workout and why it is essential to create the best workout you can have. Make sure to comment if you have any questions or share this with your friends to make sure everyone is clued up on what they're taking in their supplements!

L-Citrulline (Pure L-Citrulline, Not L-Citrulline Malate)

At the core of NEUPHORIC is L-Citrulline, a critical element for enhancing Nitric Oxide (NO) production , facilitating improved blood flow and nutrient delivery to muscles , a.k.a the pump. Unlike L-Arginine, L-Citrulline circumvents liver metabolism, ensuring an efficient metabolisation to Arginine and an elevation in NO levels^[1]. That's why including L-Arginine in a pre-workout is pointless - it may not make logical sense but L-Citrulline is more effective at converting into Arginine (the part of the NO Cycle that produces NO) than L-Arginine itself!

This mechanism promotes superior vascularity, unparalleled muscle pumps, and heightened physical performance . Clinical evidence supports L-Citrulline's efficacy in boosting muscular endurance by 52.92% and reducing muscle soreness by 40%^[2], making it a cornerstone ingredient in the NEUPHORIC formula.

In terms of dosing, the minimum effective dose is 3,000mg of pure L-Citrulline, with the maximum efficacious dose being 10,000mg ^[3]. Clicking here will take you straight to the product page so you can make use of this massive dose right away.

Why Not L-Citrulline Malate?

A lot of companies use L-Citrulline Malate in their pre-workouts. Whilst Malic Acid (the Malate part) can be useful, most companies include it simply to boost the appearing dose of L-Citrulline. Furthermore, most of these companies don't chemically bond the Malic Acid to the L-Citrulline, they simply mix it in a big vat. This doesn't provide the same benefit they are claiming it does.

Glycerol (Glycersize®)

Proper hydration is pivotal for optimal performance. Glycerol, integrated as Glycersize®, is pivotal in maintaining hydration, extending the 'hyper-hydration' effect on cellular levels, thereby bolstering endurance and enhancing both aerobic and anaerobic capacities.

The drop in osmolarity from drinking lots of water but not taking Glycerol causes your body to remove most of this excess water via the kidneys, so by taking Glycerol you can extend the duration this water is inside of your body and utilise the full hydration you get.

Glycerol has been shown to increase endurance by as much as 24% and also improves aerobic and anaerobic power and performance^[4][5]. The innovative formulation of Glycersize® ensures the stability and efficacy of the product, preventing the common issue of clumping found in traditional pre-workout supplements. It utilises a spray drying technology to yield this stable powder form of Glycerol.

Despite that, due to the giant dose of 4,000mg, your NEUPHORIC may still be slightly clumpy/have sandy texture if you don't mix it enough. Make sure you stir/shake frequently to ensure a smooth drink.

Nitrosigine® (Bonded Arginine-Silicate)

Nitrosigine®, a patented Bonded Arginine Silicate complex, is a non-stimulant powerhouse designed for peak sports performance.

Clinically backed by 30 studies, Nitrosigine enhances nitric oxide (NO) production, crucial for increased blood flow, focus, and energy. Its unique arginine and silicon blend amplifies vasodilation and blood flow more effectively than either ingredient alone. Arginine boosts NO levels for better muscle perfusion, while silicon strengthens arterial walls, enhancing their flexibility.

Remarkably, Nitrosigine sustains elevated arginine and silicon blood levels for up to six hours with just a single dose. A 2020 University of Arkansas study highlighted its potency: 1.5g of Nitrosigine matched the vasodilation effects of 8g of Citrulline Malate, underscoring its superior efficacy ^[21].

Caffeine Anhydrous & Di-Caffeine Malate

The dual inclusion of Caffeine Anhydrous and Di-Caffeine Malate offers a comprehensive energy matrix. Caffeine Anhydrous rapidly mobilizes the central nervous system, enhancing alertness, improving power output, training volume and delays fatigue by antagonising adenosine receptors. Furthermore, caffeine increases energy expenditure which can lead to making it easier to stay lean.

Also, due to caffeine's inhibition of the adenosine receptors, it also indirectly affects the release of:

Increases Norepinephrine: increases blood flow throughout the body, simulating stressful situations and stimulates glycogenolysis which increases blood glucose levels and creates readily available energy.
Increases Dopamine: results in increased feelings of pleasure, satisfaction and motivation.
Increases Glutamate secretion: responsible for shaping learning and memory.
Decreases GABA secretion: prevents the reduction in neurotransmitter excitability and allowing nerve transmission, which is essential for activity.
Increases Serotonin: responsible for learning, memory and happiness.
Increases Acetylcholine: triggers firing of motor neurones and affecting voluntary movements in nerve transmission.

Di-Caffeine Malate complements this with a buffered, sustained energy release, mitigating the potential for post-workout crashes. This synergistic blend not only maximises cognitive function but also supports increased energy expenditure for a more efficient workout.

This ingredient is a case where using Malic Acid has positive effects on the actual chemical composition: the Malic Acid is chemically bound to 2 molecules of caffeine to inhibit/slow down the release, leading to the buffered, sustained energy.

L-Theanine

L-Theanine is incorporated to balance and refine the energetic impact of caffeine, fostering a state of relaxed alertness, improving focus, and mitigating stress without inducing sedation^[6]. This balanced approach ensures a smooth, sustained energy level conducive to intense training sessions, enhancing cognitive functions essential for a focused and productive workout.

CDP Choline

Disclaimer: CDP Choline used to be Alpha GPC however due to changing legality in the UK you can no longer use Alpha GPC inside pre-workouts. That being said, we have equated the choline content using CDP Choline so even though Alpha GPC would be our first choice, you're still getting the same amount of choline.

CDP Choline (Citicoline) is a highly bioavailable and premium form of choline, known for its ability to quickly deliver choline to the brain by crossing the blood-brain barrier. It supports enhanced cognitive functions, such as memory, learning, and focus, while also promoting neural health and energy metabolism. Additionally, CDP Choline plays a key role in the synthesis of acetylcholine, a critical neurotransmitter for cognitive processing and mental clarity.^{[7][8][9][10]}

Proven to improve attention, mental endurance, and overall brain performance, CDP Choline integrates cognitive enhancement with sustained mental energy, making it an essential ingredient in the NEUPHORIC formula.^[11][12]

L-Tyrosine

L-Tyrosine is essential for synthesizing critical neurotransmitters, promoting improved cognitive flexibility, mood, and concentration, particularly under conditions of stress or fatigue^[14][15]. Furthermore, a study with the use of 2,000mg L-Tyrosine provided results that it increases cognitive flexibility^[16], so it can be useful outside of the gym too!

These effects occur because L-Tyrosine is a direct precursor to Thyroxine and to the neurotransmitters Dopamine, Epinephrine and Norepinephrine.

L-Tyrosine ➡️ L-DOPA ➡️ Dopamine ➡️ Norepinephrine (Noradrenaline) ➡️ Epinephrine (Adrenaline)

This ensures sustained mental sharpness and motivation throughout the most challenging workouts.

Why L-Tyrosine And Not N-Acetyl L-Tyrosine?

Great question! L-Tyrosine is the most bioavailable form of Tyrosine and N-Acetyl L-Tyrosine inefficiently converts into Tyrosine, even by an IV drip, and therefore doesn't elevate plasma Tyrosine levels to the same extent as L-Tyrosine.

Huperzine A:

Huperzine A, by inhibiting acetylcholinesterase, elevates acetylcholine levels, thereby enhancing cognitive function and muscle contraction. This dual-action benefit is pivotal for ensuring optimal performance where mental and physical demands intersect.

It has been shown in studies to enhance memory, focus, overall cognitive function and learning performance^[17][18][19].

Furthermore, despite acting on choline transmission, some evidence from a rodent model study has suggested that it may also influence levels of other neurotransmitters, such as Dopamine and Norepinephrine ^[20].

Black Pepper Extract

The inclusion of Black Pepper Extract is strategic, enhancing the bioavailability and effectiveness of each ingredient within NEUPHORIC, ensuring maximum absorption and sustained impact of the supplement's potent components.

It achieves this by being a very effective CYP3A4 and P-glycoprotein inhibitor. Basically, these enzymes that it inhibits break down molecules in the body, so by inhibit thyme it can prolong the effects of the increases.

In addition, as Black Pepper Extract is an MAO inhibitor, it is also believed to help manage and treat feelings of depression as well as other neurological illnesses due to MAO breaking down neurotransmitters like Dopamine, Serotonin and Norepinephrine. So by inhibiting its activity, it can allow the effects of these neurotransmitters to be retained in the body.

Why NEUPHORIC Stands Apart

NEUPHORIC transcends the conventional pre-workouts offered, providing a scientifically backed, synergistically optimised supplement.

It is designed not merely to prepare you for your workout but to redefine the boundaries of your physical and cognitive capabilities. With NEUPHORIC, experience the pinnacle of endurance, focus, and performance enhancement. Elevate your training to unprecedented levels.

Embrace the potential within and redefine your limits with NEUPHORIC.

p.s did I mention NEUPHORIC has free shipping if you spend over £50???

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073798/

[2] https://pubmed.ncbi.nlm.nih.gov/20386132/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073798/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/

[5] https://pubmed.ncbi.nlm.nih.gov/20092365/

[6] https://pubmed.ncbi.nlm.nih.gov/31623400/

[7] https://pubmed.ncbi.nlm.nih.gov/23390000/

[8] https://pubmed.ncbi.nlm.nih.gov/22447828/

[9] https://pubmed.ncbi.nlm.nih.gov/9339292/

[10] https://pubmed.ncbi.nlm.nih.gov/24375506/